#11 ESTROGENS ROLE IN BPH CONTINUED

# 11

Estrogen stimulates proliferation of stromal cells in the prostate gland that cause the urinary discomforts. A 2008 study documents specific mechanism by which estradiol causes rapid proliferation of prostate stromal cells. Researchers concluded these findings support the hypothesis that estrogen plays a role in the pathogensis of BPH, a disease charaterized predominantly by stromal overgrowth.

Peer Review Journal quoted from ------------

OESTROGEN AND BPH : EFFECTS ON STROMAL CELL PROLIFERATION AND LOCAL FORMATION FROM ANDROGEN.
J ENDOCRINOL. 2008 JAN; 197 (3) 483- 91